Pyrrha Omega is probably one of Natsu's worst match-up.
Pyrrha Omega can be really bothersome for Patroklos.
Pyrrha Omega mirror : no comment, you juste have to play better than your opponent
Pyrrha Omega vs Tira : Punish GS 3B.
Tira does can take those finely, if you don't want to deal with mirror matches, Xiba may have a shoot if you know how to play him, also you can take those with dangerous and uncommon choice like Voldo hoping for lack of knowledge