Lizardman: As long as you avoid 1A series, you should be fine. 1A series on block leads to 60+ points. But 2A+B is safe, 2K and FCK are only worth 10 points and 11A is mid risk/high reward since is 36. Setsuka has the advantage in risk/reward.
Sophitia: All her lows get punished by Sophitia for 50+ points. Avoid going low in this fight. Focus on safe mid offense and punishing. Sophitia has the advantage in risk/reward.
Amy: Avoid 1A series if you can and go with the rest of her lows. Even with them all being punishable, the damage is insignificant compared to the possible gains. Setsuka has the advantage in risk/reward.
Setsuka: Same as Sophitia. Avoid using lows as much as you can since all of them are punishable and the minimun you get in punishment is 35 and it can go all the way to 90 depending of the low. As with Sophitia, play a patient and punishing game as much as you can.