Crimzin
[12] Conqueror
There I think it becomes a matter of preference. I find Aeon's situation more impactful, since he's been put through this gauntlet of misfortune, and at the end of it (which isn't really the end, since he's still a lizard), the god he's pledged himself to won't even speak to him. It's a pretty cold, direct betrayal.
Cassandra has more of a secondhand anger, and though she doesn't like Hephaestus, she's still doing his bidding, just on behalf of her sister.
It's a shame there haven't been any canon encounters between Cassandra and Aeon. Seems like they'd be on the same page.
That's what I'm hoping happens with SCVI's story. If it's a soft reboot then there can be new character interactions and slight changes to the plot.
I wonder how far they would go? Like if the events start from Soul Blade, I wonder if they would do something ballsy like instead of having Siegfried getting taken over by Soul Edge Mitsurugi is. Nightmare would be a Demon Samurai instead of Knight.
There is quite a lot of interesting possibilities that could happen.